Antigen-specific CD4+ T cells

Biomarker

1 paper1 finding

  • Animals1

Interventions

1

Polyanhydride nanoparticles + pentablock copolymer micelles + cyclic dinucleotides

upin mice1

1 study
  1. Polyanhydride nanoparticles + pentablock copolymer micelles + cyclic dinucleotides increase antigen-specific CD4+ T cells in mice.

    “a combination nanovaccine composed of NP, Mi, and CDN administered to aged mice resulted in a greater percentage of antigen-specific CD4+ T cells”

    Animalsdraining lymph nodes

    Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines

    Immunity & ageing : I & AJun 21, 2023

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Journal of Translational Medicine

Some T cell responses were weaker in older COVID-19 survivors

An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older…An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older adults.

Cohort studyImmune response