Amyloid-beta plaque deposition
5 papers2 findings
- Humans1
- Animals3
Interventions
1Aav-hevin
no changein mice1
1 study
Aav-hevin
no changein mice1
Aav-hevin has no effect on amyloid-beta plaque deposition in mice.
“Hevin overexpression did not influence the deposition of Aβ plaques in the hippocampus”
Animalsin middle-aged APP/PSEN micehippocampus
Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Aging cell12 Feb 2025
Associations
1Intraneuronal amyloid-beta accumulation
upin mice1
1 study
Intraneuronal amyloid-beta accumulation
upin mice1
Intraneuronal amyloid-beta accumulation is associated with amyloid-beta plaque deposition in mice.
“Intracellular accumulation of aggregated Aβ in the CA1 pyramidal cells at 9 months preceded extracellular plaques that first presented in the CA1 at 16 months of age.”
Animalsin 3xTg-AD miceCA1 pyramidal cells
Journal of Alzheimer's disease : JAD1 Jan 2022
Latest
1 in 12 monthsAging and Disease
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI
Study of 300 peopleGFAP
Brain Communications
Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease
Cohort study of 156 peopleMechanisms
Aging Cell
Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Experiments in miceInterventions
Journal of Alzheimer's Disease
Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model
Experiments in miceMechanisms