AgingResearch.NewsJoin free

Aav-hevin

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 6 more
  • Animals1

Outcomes

4

Cognitive function

upin mice1

1 study

  1. Aav-hevin improves cognitive function in mice.

    “revealing improved cognitive performance following astrocytic Hevin overexpression”

    Animalsin middle-aged wild-type animalshippocampus

    Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

    Aging cell12 Feb 2025

Amyloid-beta plaque deposition

no changein mice1

1 study

  1. Aav-hevin has no effect on amyloid-beta plaque deposition in mice.

    “Hevin overexpression did not influence the deposition of Aβ plaques in the hippocampus”

    Animalsin middle-aged APP/PSEN micehippocampus

    Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

    Aging cell12 Feb 2025

More on Amyloid-beta plaque deposition

Synapse

upin mice1

1 study

  1. Aav-hevin increases synapse in mice.

    “increased pre- and postsynaptic markers colocalization, and altered expression of synaptic mediators”

    Animalsin hippocampal astrocytes of middle-aged APP/PSEN micehippocampus

    Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

    Aging cell12 Feb 2025

Cognitive decline

downin mice1

1 study

  1. Aav-hevin decreases cognitive decline in mice.

    “Hevin overexpression attenuates cognitive decline, as evidenced by cognitive tests”

    Animalsin hippocampal astrocytes of middle-aged APP/PSEN micehippocampus

    Astrocytic Hevin/SPARCL-1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

    Aging cell12 Feb 2025

Latest

Related