Intraneuronal amyloid-beta accumulation

1. Cysteine decreases intraneuronal amyloid-beta accumulation in mouse cells.

   “iAβ accumulation was lowered in cultured middle-age adult 3xTg-AD neurons by treatment of the oxidized redox state in the neurons with exogenous cysteine.”

   Cellsin cultured middle-age adult 3xTg-AD neuronsneurons

   Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model

   Journal of Alzheimer's disease : JAD·1 Jan 2022

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1. Intraneuronal amyloid-beta accumulation is associated with amyloid-beta plaque deposition in mice.

   “Intracellular accumulation of aggregated Aβ in the CA1 pyramidal cells at 9 months preceded extracellular plaques that first presented in the CA1 at 16 months of age.”

   Animalsin 3xTg-AD miceCA1 pyramidal cells

   Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model

   Journal of Alzheimer's disease : JAD·1 Jan 2022

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