Amyloid and tau pathology

Biomarker

1 finding

Associations

1

Mild cognitive impairment or dementia

upin humans1

1 study
  1. Amyloid and tau pathology predicts mild cognitive impairment or dementia in humans (>50%).

    “>50% of CU with high amyloid and tau progress to MCI/dementia within 5 years”

    Reviewcognitively unimpaired individuals with high amyloid and tau5 years

    Alzheimer's Disease Begins Years Before Symptoms: Alzheimer's Association Workgroup

    AAIC 2025 abstract9 Jan 2026

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Age and Ageing

Immune cell profiles predict cognitive decline in older adults

In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.In 4,464 cognitively normal older adults, a higher immune risk score predicted incident cognitive impairment or dementia with a hazard ratio of 1.63 over six years.

Cohort study of 9,008 peopleBiomarkers