AD biomarkers
Biomarker1 paper
- Human trial1
Funding
National Institute on AgingUS$2.8mVeterans Affairs4 grants since 2022
Returning AD biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact
National Institute on AgingWashington UniversityUS$650.7k2024–2029
National Institute on AgingBrigham and Women's HospitalUS$1.4m2022–2027
Personalized OSA treatment and effects on AD biomarkers and cognition among blacks
National Institute on AgingUniversity of Miami School of MedicineUS$743.8k2022–2028
Latest
199Lifestyle trial found similar Alzheimer’s blood marker changes
A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.A two-year randomised trial in 1,260 older adults at risk of dementia found no clear evidence that starting blood markers altered cognitive benefits.
Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults
Disadvantaged neighborhoods tie to lower brain vascular function
In 132 older adults, greater neighborhood deprivation was associated with lower whole-brain cerebrovascular reactivity, independent of traditional…In 132 older adults, greater neighborhood deprivation was associated with lower whole-brain cerebrovascular reactivity, independent of traditional vascular risks and Alzheimer's pathology.
Plasma p-tau217 yields discordant Alzheimer results in 8.5% of adults
False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and…False-negative blood results occurred in 5.6% of participants compared with false positives in 2.8%, with mismatches tied to kidney function, BMI, and clinical stage.
Voice taxonomy detects cognitive decline and Alzheimer markers
In 1,479 participants across three cohorts, a new voice taxonomy differentiated mild cognitive impairment with an effect size of d = −0.39 and tracked…In 1,479 participants across three cohorts, a new voice taxonomy differentiated mild cognitive impairment with an effect size of d = −0.39 and tracked cognitive change.