Alpha-secretase activity

2 papers1 finding

Animals1
Cells1

Upstream

1

SIRT1

upin mice1

1 study

SIRT1 increases alpha-secretase activity in mice.
“expression of exogenous human (h) SIRT1 in the brain of hSIRT1 transgenics also resulted in decreased ROCK1 expression and elevated alpha-secretase activity in vivo.”
Animalsbrain
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
The Journal of biological chemistry2 Jun 2006

Latest

Annals of the New York Academy of Sciences1 Dec

Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

Experiments in miceDietary restriction

The Journal of Biological Chemistry2 Jun

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

Experiments in mouse cellsDietary restriction