Journal of Neuroinflammation
Protein loss promotes age-linked brain cell activation in mice
In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.
Experiments in adult and aged mice, against aged control miceMechanisms
Limit: Whether activation is adaptive or an early, compensated stage of chronic activation remains unknown