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P16INK4A-SIRNA-LOADED nanoparticles

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Ministry of Science and ICT, South Korea and 2 more
  • Animals1

Outcomes

3

Cognitive function

upin mice1

1 study

  1. P16INK4A-SIRNA-LOADED nanoparticles improve cognitive function in mice.

    “reversed learning deterioration and spatial memory deficits”

    Animalsin 5XFAD mice

    Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer's disease

    Molecular neurodegeneration16 Mar 2024

Aged microglia surrounding the plaque

downin mice1

1 study

  1. P16INK4A-SIRNA-LOADED nanoparticles decrease aged microglia surrounding the plaque in mice.

    “reduced amyloid plaque formation and the number of aged microglia surrounding the plaque”

    Animalsin 5XFAD mice

    Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer's disease

    Molecular neurodegeneration16 Mar 2024

More on Aged microglia surrounding the plaque

Amyloid plaque formation

downin mice1

1 study

  1. P16INK4A-SIRNA-LOADED nanoparticles decrease amyloid plaque formation in mice.

    “Nanoparticle-based delivery of p16ink4a siRNA reduced amyloid plaque formation”

    Animalsin 5XFAD mice

    Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer's disease

    Molecular neurodegeneration16 Mar 2024

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