8-oxo-2'-deoxyguanosine

4 papers2 findings

Animals4

Interventions

1

Memantine

downin rats1

1 study

Memantine decreases 8-oxo-2'-deoxyguanosine in rats.
“After two weeks of treatment, an increase in TP53 protein level and a decrease in 8-oxo-2'deoxyguanosine (8-oxo-2'dG) level were observed.”
Animalsagingintragastric injectionbraintwo weeksfemalesn = 21
Expression of Neuronal Nicotinic Acetylcholine Receptor and Early Oxidative DNA Damage in Aging Rat Brain-The Effects of Memantine
International journal of molecular sciencesFeb 14, 2025

More on Memantine

Upstream

1

Spontaneous dwarf rat

downin rats1

1 study

spontaneous dwarf rat decreases 8-oxo-2'-deoxyguanosine in rats.
“Decreased 8-oxo-2'-deoxyguanosine (8-oxodG) content, a marker of oxidative DNA damage, indicated suppressed oxidative stress in the liver, kidney, and lung of SDRs.”
Animalsspontaneous dwarf ratliver, kidney, and lung
Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality
Experimental gerontologyFeb 20, 2013

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Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality

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Does oxidative damage to DNA increase with age?

Experiments in ratsInterventions

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