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8-oxo-7,8-dihydroguanosine

Biomarker

2 papers2 findings

  • Humans1
  • Animals1

Upstream

1

Psychiatric illness

upin humans1

1 study

  1. Psychiatric illness increases 8-oxo-7,8-dihydroguanosine in humans (2.4 vs 2.2 nmol/mmol, P < .001).

    “Mean (SD) baseline 8-oxoGuo was statistically significantly higher in individuals with psychiatric illness than in those without (2.4 [1.2] nmol/mmol vs 2.2 [0.9] nmol/mmol; P < .001)”

    Humansn = 7,728

    Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness

    JAMA psychiatryMar 6, 2024

More on Psychiatric illness

Associations

1

Mortality

upin humans1HR 1.99

1 study

  1. 8-oxo-7,8-dihydroguanosine predicts mortality in humans (HR 1.99, 95% CI 1.58-2.52).

    “increased sequentially with each increasing tertile of 8-oxoGuo excretion in both groups to an almost doubled risk in the psychiatric illness/high 8-oxoGuo group compared to the no psychiatric illness/low 8-oxoGuo reference group (HR, 1.99; 95% CI, 1.58-2.52; P < .001)”

    Humansup to 16.0 yearsn = 7,728

    Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness

    JAMA psychiatryMar 6, 2024

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