4E-BP1 phosphorylation

1. Voluntary wheel running increases 4E-BP1 phosphorylation in mice (light cycle, Apc (MIN) mice).

   “Voluntary wheel running increased light cycle MIN 4E-BP1 phosphorylation and attenuated muscle mass loss.”

   Animalslight cycle, Apc (MIN) miceskeletal muscle2 wkmalesn = 19

   Cachexia Disrupts Diurnal Regulation of Activity, Feeding, and Muscle Mechanistic Target of Rapamycin Complex 1 in Mice

   Medicine and science in sports and exercise·Oct 25, 2019

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1. Ethanol showed no clear effect on 4E-BP1 phosphorylation in mice (refeeding-induced increase).

   “while ethanol prevented a nutrient-stimulated increase in S6K1 phosphorylation, it did not alter the increase in 4E-BP1 phosphorylation.”

   Animalsrefeeding-induced increaseskeletal muscle3 g/kgmales

   Ethanol acutely antagonizes the refeeding-induced increase in mTOR-dependent protein synthesis and decrease in autophagy in skeletal muscle

   Molecular and cellular biochemistry·Dec 6, 2018

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1. 4E-BP1 phosphorylation is associated with cachexia progression in mice (end of light cycle, Apc (MIN) mice).

   “MIN 4E-BP1 phosphorylation at the end of the light cycle was significantly correlated with cachexia progression and reduced physical activity.”

   Animalsend of light cycle, Apc (MIN) micegastrocnemius musclemalesn = 22

   Cachexia Disrupts Diurnal Regulation of Activity, Feeding, and Muscle Mechanistic Target of Rapamycin Complex 1 in Mice

   Medicine and science in sports and exercise·Oct 25, 2019

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