20S proteasome

Biomarker

3 papers1 finding

Human trial1
Animals2

Upstream

PSMB8

downin mice1

1 study

PSMB8 decreases 20S proteasome in mice.
“20S proteasome activity was significantly reduced in the spleen”
Animalshomozygous founder variant G201Vspleen
The homozygous founder Psmb8 variant of Nakajo-Nishimura syndrome/proteasome-associated autoinflammatory syndrome causes panniculitis-associated lipoatrophy and a shortened lifespan in mice
Scientific reports28 May 2026

Latest

3 in 12 months

Frontiers in Aging6 Jul

Sex-specific remodeling of proteasome complexes in lymph nodes of aged BTBR mice

Experiments in miceUbiquitin–proteasome system

Paper

Scientific Reports29 May

The homozygous founder Psmb8 variant of Nakajo-Nishimura syndrome/proteasome-associated autoinflammatory syndrome causes panniculitis-associated lipoatrophy and a shortened lifespan in mice

Experiments in miceUbiquitin–proteasome system

Paper

Experimental Biology and Medicine30 Mar

Enhanced oxidative stress resilience in C. elegans acox-1.1 mutants through CTL-3 and proteasomal regulation

Experiments in wormsFatty acid β-oxidation

Paper

Voprosy Kurortologii, Fizioterapii, I Lechebnoi Fizicheskoi Kultury12 Dec

The ratio of autophagy activity and protein resynthesis in patients undergoing a wellness program in combination with food deprivation

Non-randomised trial in 48 peopleInterventions

Paper

Science Advances10 Oct

Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins

Experiments in wormsUbiquitin–proteasome system

Paper

Aging Cell13 Feb

Proteasome Augmentation Mitigates Age-Related Cognitive Decline in Mice

Experiments in animalsInterventions

Paper

International Journal of Molecular Sciences27 Nov

The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease

ReviewCellular senescence

Paper

bioRxiv28 Oct

Altered Proteasome Composition in Aging Brains, Genetic Proteasome Augmentation Mitigates Age-Related Cognitive Declines, and Acute Proteasome Agonist Treatment Rescues Age-Related Cognitive Deficits in Mice

Preprint: experiments in animalsInterventions

Paper

Cells15 Oct

Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function

Experiments in cellsMechanisms

Paper

bioRxiv15 Apr

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins

Preprint: experiments in model organismsMechanisms

Paper