Bradley F. Boeve
Mayo Clinic3 papersORCID 0000-0002-4153-8187OpenAlex
Papers
Nature CommunicationsIn silico
Brain metabolism model predicts Alzheimer tau in humans
Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with…Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with 79% to 95% accuracy.
bioRxivHumansPreprint
Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who…Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.