Advanced CKM syndrome is linked to higher suicide risk

In a nationwide cohort of 4,601,001 Korean adults from the Korean National Health Insurance Service database, researchers examined whether the Cardiovascular-Kidney-Metabolic (CKM) syndrome framework associates with suicide-related mortality. Participants were categorized into CKM stages 0 through 4 and followed for a median of 10.11 years, during which 12,034 suicidal deaths occurred.

After adjusting for clinicodemographic variables, comorbidities, and claims-based psychiatric diagnoses, advanced CKM stages correlated with increased risk of suicidal death, yielding adjusted hazard ratios of 1.328 for stage 3 and 1.319 for stage 4. In Fine-Gray models accounting for non-suicide death as a competing event, associations remained significant, with subdistribution hazard ratios of 1.199 for stage 3 and 1.246 for stage 4. Exploratory subgroup analyses showed the association was most pronounced in adults aged 20 to 39 and in individuals without a claims-based diagnosis of depression.