Imidazopyrroloquinoline

Imidazopyrroloquinoline has been studied in 3 papers since 2026: none in people yet, 3 in animals; 3 in the past year. The research so far is in animals. The newest paper, Feb 25, 2026: “Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice”.

Intervention

3 papers study it9 findingsUpdated Feb 25, 2026

See all 3

None of its findings points the other way.

1 lab in 1 country

9 of 9 findings with company ties

Animals3

What did studies of Imidazopyrroloquinoline find?

Studies of Imidazopyrroloquinoline measured 5 outcomes; the most studied are lipid accumulation (2 studies), lifespan (2) and neuromuscular function (1).

Lipid accumulation

downin mice2

2 studies

Imidazopyrroloquinoline decreases lipid accumulation in SAMP8 mice.
“We also found that IPQ intake reduced lipid accumulation in adipose tissue and the liver.”
Animalsin SAMP8 miceadipose tissue and liver0.02% (w/w)
Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice
ChemRxivFeb 25, 2026Preprint
Imidazopyrroloquinoline decreases lipid accumulation in mice.
“IPQ intake reduced lipid accumulation in adipose tissue and the liver.”
Animalsadipose tissue and liver
Two dietary compounds prolonged survival in short-lived mice
Food & functionJan 1, 2026

Lifespan

upin mice2+30%

2 studies

Imidazopyrroloquinoline extends lifespan in mice (lifelong supplementation in SAMP8 mice) (~30%).
“the day of 75% survival was prolonged by approximately 60% and 30% in the PQQ and IPQ groups, respectively, compared with that in control.”
Animalslifelong supplementation in SAMP8 mice0.02% (w/w)
Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice
ChemRxivFeb 25, 2026Preprint
Imidazopyrroloquinoline extends lifespan in mice (lifelong supplementation) (+36% 75th percentile survival days).
“In lifelong experiments, the survival days at the 75th percentile was prolonged by 73% and 36% in the PQQ and IPQ groups, respectively, compared with that in the control.”
Animalslifelong supplementation0.02% (w/w)
Two dietary compounds prolonged survival in short-lived mice
Food & functionJan 1, 2026

Neuromuscular function

upin mice1

1 study

Imidazopyrroloquinoline improves neuromuscular function in mice (lifelong or midlife supplementation in SAMP8 mice).
“intake of PQQ and IPQ diets from midlife improved neuromuscular function that had declined with age.”
Animalslifelong or midlife supplementation in SAMP8 mice0.02% (w/w)
Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice
ChemRxivFeb 25, 2026Preprint

Physical function

upin mice1

1 study

Imidazopyrroloquinoline improves physical function in mice (midlife supplementation).
“intake of PQQ and IPQ diets from midlife improved neuromuscular function that had declined with age.”
Animalsmidlife supplementation0.02% (w/w)
Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice
ChemRxivFeb 18, 2026Preprint

Muscular function

upin mice1

1 study

Imidazopyrroloquinoline improves muscular function in mice (midlife supplementation).
“Intake of PQQ and IPQ diets from midlife improved muscular function that had declined with age.”
Animalsmidlife supplementation0.02% (w/w)
Two dietary compounds prolonged survival in short-lived mice
Food & functionJan 1, 2026

Latest

3 papers in 12 months

ChemRxivFeb 25

Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice

Preprint: experiments in miceInterventions

Paper

ChemRxivFeb 18

Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice

Preprint: experiments in miceInterventions

Paper

Food & FunctionJan 1

Two dietary compounds prolonged survival in short-lived mice

Survival days at the 75th percentile increased by 73% with pyrroloquinoline quinone and 36% with imidazopyrroloquinoline in lifelong feeding experiments, compared with…Survival days at the 75th percentile increased by 73% with pyrroloquinoline quinone and 36% with imidazopyrroloquinoline in lifelong feeding experiments, compared with controls.

Mouse studyInterventions

Paper

Imidazopyrroloquinoline

What did studies of Imidazopyrroloquinoline find?

Latest

Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice

Pyrroloquinoline quinone and imidazopyrroloquinoline intake extend healthy lifespan and improve physical dysfunctions with age in mice

Two dietary compounds prolonged survival in short-lived mice

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