Effect of caloric restricted diet on the liver microsomal monooxygenase system in rats of various ages

Dietary restriction is the only known experimental method to extend lifespan in mammals, but the mechanisms of this phenomenon are still unknown. It is determined that the keeping of animals on the calorie restricted diet results in essential changes of a drug-metabolizing enzymes contents, that is also confirmed by the change of response of the enzyme system to thyroxine action. As a whole, the results obtained will be coordinated with the point of view, according to which the action mechanisms of the dietary restriction consist in considerable change of a wide spectrum of biochemical processes, including the change of the level of monooxygenase system functioning.