Distinct Risk Profiles for Cardiovascular and Cancer Mortality in People with Diabetes from the UK Biobank

Introduction and Objective: Cardiovascular disease and cancer are leading causes of death in people with diabetes. We aimed to compare their associated risk profiles. Methods: We studied 28,043 adults with diabetes from the UK Biobank and compared cardiovascular and cancer mortality using cause-specific Cox models adjusted for key demographic and clinical factors. Results: Over a median follow-up of 11.8 years, 6,037 deaths occurred (28.4% cardiovascular; 24.5% cancer). Cardiovascular mortality was strongly associated with male sex (HR 2.39, 95% CI 2.12-2.71) and dementia (HR 1.81, 95% CI 1.52-2.17). Cancer mortality was most strongly associated with smoking (HR 1.52, 95% CI 1.34-1.73), while dementia showed an inverse association. Conclusion: Cardiovascular and cancer mortality in diabetes display distinct risk profiles, supporting phenotype-informed risk stratification. Disclosure: J. Calvo-Marin: Speaker's Bureau; Current; Novo Nordisk, AstraZeneca, Abbott Diabetes, Roche Diabetes Care. V. Mora-Gomez: None. F. Ruiz Salazar: Speaker's Bureau; Current; Abbott Diagnostics, AstraZeneca, Novo Nordisk A/S. Advisory Panel; Current; Roche Diagnostics. M. Lutz: None. G. Torrealba-Acosta: None.