WPD-SEVSSIMDM2

1. WPD-SEVSSIMDM2 decreases cellular senescence in human cells.

   “In ex vivo cultured human OA cartilage explants, it is confirmed that WPD-sEVssiMDM2 alleviates senescent phenotype.”

   Cellsex vivo cultured human OA cartilage explants

   Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·4 Jan 2025

2. WPD-SEVSSIMDM2 decreases cellular senescence in mice.

   “In both post-traumatic OA mice and naturally aged mice, WPD-sEVssiMDM2 more effectively eliminates senescent chondrocytes”

   Animalsin post-traumatic OA mice and naturally aged mice

   Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·4 Jan 2025

More on Cellular senescence

1. WPD-SEVSSIMDM2 improves cellular homeostasis in mice.

   “In both post-traumatic OA mice and naturally aged mice, WPD-sEVssiMDM2 more effectively eliminates senescent chondrocytes and maintained matrix metabolic homeostasis.”

   Animalsin post-traumatic OA mice and naturally aged mice

   Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·4 Jan 2025

More on Cellular homeostasis