Wildfire smoke

1. Wildfire smoke increases faster aging in rhesus monkeys.

   “Infant macaques showed immune changes and signs of faster aging years after inhaling smoke.”

   Animals

   Single wildfire smoke exposure causes lasting harm, natural experiment in monkeys hints

   Science (New York, N.Y.)·24 Sep 2026

1. Wildfire smoke activates NF-κB signalling in human cells.

   “NF-κB p65 nuclear translocation, observed at 24 hours, highlighted its critical role in cytokine release and inflammation following exposure to DEP and WFSE.”

   Cellsextractmonocyte-derived microglia-like cells24 hours

   Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia

   bioRxiv (Cold Spring Harbor Laboratory)·20 Dec 2024Preprint

More on NF-κB signalling

1. Wildfire smoke induces inflammation in human cells.

   “WFSE triggered a delayed but sustained inflammatory response, with TNF-α, IFN-γ, IL-23, and IL-33 levels persisting at 96 hr in aged MDMi”

   CellsCells derived from healthy older individualsextractmonocyte-derived microglia-like cellsPersisting at 96 hours

   Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia

   bioRxiv (Cold Spring Harbor Laboratory)·20 Dec 2024Preprint

More on Inflammation

1. Wildfire smoke increases HMOX1 in human cells.

   “DEP and WFS extract (WFSE) significantly upregulated expression of the oxidative stress marker, heme-oxygenase-1 (HO-1) in MDMi after 24 hr”

   Cellsextractmonocyte-derived microglia-like cells24 hours

   Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia

   bioRxiv (Cold Spring Harbor Laboratory)·20 Dec 2024Preprint

More on HMOX1