Weight-adjusted waist index
Weight-adjusted waist index has been studied in 11 papers since 2022: 11 observational studies in people; 4 in the past year. The newest paper, Oct 3, 2026: “Sex-specific associations of traditional and novel anthropometric indices with incident kidney stone disease: a 10-year longitudinal cohort study”.
11 papers study it7 findingsUpdated
1 new paper in 30 daysSee all 11
“each unit increase in WWI was significantly associated with a decrease in Klotho by 23.18 ng/ml”
None of its findings points the other way.
- 4 independent labs in 1 country
- Funder: China Postdoctoral Science Foundation
- Humans11
What is Weight-adjusted waist index linked with?
7Studies link Weight-adjusted waist index with 7 measures, most often cognitive decline (1 study), crystallized cognitive function (1) and fluid cognitive function (1).
Cognitive decline
upin humans1
1 study
Cognitive decline
upin humans1
Weight-adjusted waist index is associated with cognitive decline in humans (highest tertile vs lowest tertile) (cumulative deficit of 0.141 SD over 10 years).
“Compared with the lowest tertile (T1), the highest WWI tertile (T3) had lower baseline cognitive scores and a faster age-related cognitive decline.”
Humanshighest tertile vs lowest tertile10 yearsn = 8,240
Diabetes, obesity & metabolism
Crystallized cognitive function
downin humans1
1 study
Crystallized cognitive function
downin humans1
Weight-adjusted waist index is associated with crystallized cognitive function in humans (β = -0.046, 95% CI: -0.070, -0.022).
“crystallised cognition (β = -0.046; 95% CI: -0.070, -0.022)”
Humans1-SD increase10 yearsn = 8,240
Diabetes, obesity & metabolism
Fluid cognitive function
downin humans1
1 study
Fluid cognitive function
downin humans1
Weight-adjusted waist index is associated with fluid cognitive function in humans (β = -0.064, 95% CI: -0.089, -0.038).
“fluid cognition (β = -0.064; 95% CI: -0.089, -0.038)”
Humans1-SD increase10 yearsn = 8,240
Diabetes, obesity & metabolism
Global cognitive function
downin humans1
1 study
Global cognitive function
downin humans1
Weight-adjusted waist index is associated with global cognitive function in humans (β = -0.064, 95% CI: -0.089, -0.038).
“Each one-SD increase in WWI was linked to lower cognitive scores: global cognition (β = -0.064; 95% CI: -0.089, -0.038)”
Humans1-SD increase10 yearsn = 8,240
Diabetes, obesity & metabolism
Soluble Klotho
downin humans1
1 study
Soluble Klotho
downin humans1
Weight-adjusted waist index is associated with soluble Klotho in humans (cross-sectional NHANES analysis with weighted multivariate linear regression) (β=-0.03; 95%CI -0.04 to -0.01; p<0.0001 for WWI with Ln-sKlotho).
“There was a negative correlation between both WWI and SII and sKlotho.”
Humanscross-sectional NHANES analysis with weighted multivariate linear regressionn = 9,506
Frontiers in endocrinology
Serum α-Klotho
downin humans1
1 study
Serum α-Klotho
downin humans1
Weight-adjusted waist index is associated with serum α-Klotho in humans (survey-weighted multiple linear regression) (adjusted percent change -7.79% (95% CI -10.15, -5.37)).
“significant negative correlation between WWI and serum α-Klotho levels”
Humanssurvey-weighted multiple linear regressionn = 6,997
Scientific reports
Alpha-Klotho
downin humans1
1 study
Alpha-Klotho
downin humans1
Weight-adjusted waist index is associated with alpha-Klotho in humans after full adjustment (β = -23.18 ng/ml per unit WWI (95% CI -31.34 to -15.02)).
“each unit increase in WWI was significantly associated with a decrease in Klotho by 23.18 ng/ml”
Humansafter full adjustmentn = 13,172
Experimental gerontology