Vilon
Vilon has been studied in 17 papers since 2001: 1 trial in people, 8 in animals, 6 in cells, 2 reviews; 1 in the past year. It has not reached trials in people. The newest paper, Jun 9, 2026: “PEPTIDE BIOREGULATORS, AGING AND HUMAN LONGEVITY: EPITHALON, THYMALIN, THYMOGEN, DSIP, VILON AND VESUGEN IN CIRCADIAN BIOLOGY, TELOMERASE REGULATION AND INFLAMMAGING”.
At a glance
The findings reach mice, none yet in people. 5 independent labs in 4 countries.
1 of its findings points the other way.
- 5 independent labs in 4 countries
- 1 finding against
- Human trial1
- Animals7
- Model organisms1
- Cells6
What did studies of vilon find?
17Studies of vilon measured 17 outcomes; the most studied are reactive oxygen species (1 study), ribosomal protein L7A (1) and MitoTracker Red staining (1).
Reactive oxygen species
upin flies1downin flies1
1 study
Reactive oxygen species
upin flies1downin flies1
Vilon increases reactive oxygen species in flies.
“stimulated this process in the cytosol”
Model organismscytosol
Bulletin of experimental biology and medicine
Vilon decreases reactive oxygen species in flies.
“Vilon inhibited generation of reactive oxygen species in mitochondria”
Model organismsmitochondria
Bulletin of experimental biology and medicine
Ribosomal protein L7A
downin human cells1−15%
1 study
Ribosomal protein L7A
downin human cells1−15%
Vilon decreases ribosomal protein L7A in human cells during thymic cell senescence in vitro (15%).
“decreases on 15% the expression of ribosomal protein L7A in cultures of human thymic cells during its senescence”
Cellsduring thymic cell senescence in vitrothymus
Advances in gerontology = Uspekhi gerontologii
MitoTracker Red staining
upin human cells1
1 study
MitoTracker Red staining
upin human cells1
Vilon increases MitoTracker Red staining in human cells during thymic cell senescence in vitro (1.5 times).
“KE peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining”
Cellsduring thymic cell senescence in vitrothymus
Advances in gerontology = Uspekhi gerontologii
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Vilon decreases cellular senescence in human cells.
“KE dipeptide promotes functional activity of skin fibroblasts and inhibits their aging.”
Cellsskin fibroblast
Advances in gerontology = Uspekhi gerontologii
Sirtuin-6 expression
upin human cells1
1 study
Sirtuin-6 expression
upin human cells1
Vilon increases sirtuin-6 expression in human cells (young and old skin fibroblast cultures) (1.6 times (young), 2.6 times (old)).
“KE dipeptide increases expression area of sirtuin-6 in «young» and «old» skin fibroblasts cultures by 1,6 and 2,6 times correspondingly.”
Cellsyoung and old skin fibroblast culturesskin fibroblast
Advances in gerontology = Uspekhi gerontologii
Collagen type I expression
upin human cells1+83%
1 study
Collagen type I expression
upin human cells1+83%
Vilon increases collagen type I expression in human cells (old skin fibroblast cultures) (+83%).
“KE dipeptide increases collagen type I expression area in «old» skin fibroblasts cultures by 83%.”
Cellsold skin fibroblast culturesskin fibroblast
Advances in gerontology = Uspekhi gerontologii
Pericentromeric structural heterochromatin
no changein human cells1
1 study
Pericentromeric structural heterochromatin
no changein human cells1
Vilon showed no clear effect on pericentromeric structural heterochromatin in human cells (cultivated lymphocytes from old individuals).
“vilon does not induce deheterochromatinization of pericentromeric structural heterochromatin”
Cellscultivated lymphocytes from old individualslymphocyte
Anti-aging peptide bioregulators induce reactivation of chromatin
Georgian medical news
Heterochromatin
downin human cells1
1 study
Heterochromatin
downin human cells1
Vilon decreases heterochromatin in human cells (cultivated lymphocytes from old individuals).
“induce unrolling (deheterochromatinization) of total heterochromatin”
Cellscultivated lymphocytes from old individualslymphocyte
Anti-aging peptide bioregulators induce reactivation of chromatin
Georgian medical news
Cell cycle regulation
upin human cells1
1 study
Cell cycle regulation
upin human cells1
Vilon activates cell cycle regulation in human cells (coculture).
“this peptide promoted thymocyte transformation into proliferating blast cells”
Cellscoculture
Bulletin of experimental biology and medicine
Argyrophilic nucleolar organizer region proteins
upin human cells1
1 study
Argyrophilic nucleolar organizer region proteins
upin human cells1
Vilon increases argyrophilic nucleolar organizer region proteins in human cells (coculture).
“Vilon stimulated and Epithalon suppressed the expression of argyrophilic proteins in nucleolar organizer regions of thymocytes and epithelial cells”
Cellscoculture
Bulletin of experimental biology and medicine
All 17Fewer
What is vilon linked with?
3Studies link vilon with 3 measures, most often mammary cancer (1 study), gene expression (1) and bladder tumors (1).
Mammary cancer
upin mice1
1 study
Mammary cancer
upin mice1
Vilon raises the risk of mammary cancer in mice (p < 0.05).
“The treatment with Vilon produced significant negative effects when compared to the control group, with an increased incidence of mammary cancer development (p < 0.05)”
AnimalsLys-Glumammary gland1 microg/mousefor 5 consecutive days every monthfemales
International journal of cancer
gene expression
mixedin mice1
1 study
gene expression
mixedin mice1
Vilon is associated with gene expression in mice (36 clones).
“Vilon changed expression of 36 clones”
Animalsheart
Bulletin of experimental biology and medicine
Bladder tumors
downin rats1
1 study
Bladder tumors
downin rats1
Vilon lowers the risk of bladder tumors in rats (carcinogen-induced bladder neoplasia) (56% vs 75.5% in control).
“Treatment with Vilon was followed by a significant fall in tumor incidence in 56% of experimental animals, as compared with 75.5% in control”
Animalscarcinogen-induced bladder neoplasiaurinary bladder
Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats
Voprosy onkologii