Mammary adenocarcinoma

1. Melatonin decreases mammary adenocarcinoma in mice.

   “Constant treatment with melatonin decreased incidence and size of mammary adenocarcinomas, and incidence of lung metastases, compared to controls.”

   Animalsconstant treatment to natural death20 mg/lfemales

   The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice

   International journal of cancer·20 Jan 2003

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1. Mammary adenocarcinoma shortens lifespan in mice.

   “Life expectancy was markedly reduced by mammary and pulmonary adenocarcinoma, and by tumors of the hypophysis.”

   Animalsfemales

   Spontaneous tumors and lifespan of female NMRI mice of the outbred stock Sut:NMRT during a lifetime study

   Journal of cancer research and clinical oncology·1 Jan 1984

1. ERBB2 raises the risk of mammary adenocarcinoma in mice (100%).

   “Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas”

   Animalsin transgenic HER-2/neu micemammary glandfemales

   Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice

   Biogerontology·30 Sep 2015

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1. Phenformin lowers the risk of mammary adenocarcinoma in mice (4.0-fold).

   “The treatment significantly inhibited (4.0-fold, P < 0.01) the incidence of mammary adenocarcinomas in mice.”

   Animalschronic treatmentfemales

   Insulin and longevity: antidiabetic biguanides as geroprotectors

   Biogerontology·1 Jan 2003

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1. Thymus-derived polypeptide factors lower the risk of mammary adenocarcinoma in mice (1.8-fold decrease).

   “Both factors when administered to young mice caused a decrease in both overall tumour incidence and incidence of mammary adenocarcinomas (TF, 1.8-fold decrease; PF, 2.6-fold decrease).”

   Animalspolypeptide factors0.1 mgfemales

   Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age

   Mechanisms of ageing and development·1 Sep 1989

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1. Pineal gland-derived polypeptide factors lower the risk of mammary adenocarcinoma in mice (2.6-fold decrease).

   “Both factors when administered to young mice caused a decrease in both overall tumour incidence and incidence of mammary adenocarcinomas (TF, 1.8-fold decrease; PF, 2.6-fold decrease).”

   Animalspolypeptide factors0.1 mgfemales

   Effect of low-molecular-weight factors of thymus and pineal gland on life span and spontaneous tumour development in female mice of different age

   Mechanisms of ageing and development·1 Sep 1989

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1. Selenium lowers the risk of mammary adenocarcinoma in mice (46% incidence vs 77% control (P < 0.05)).

   “animals changed from the 0.15 ppm Se diet to that containing 1.0 ppm Se at the age of 13.8 months develop mammary tumors with a total incidence of only 46%, significantly lower (P < 0.05)”

   Animalschanged from 0.15 ppm Se diet to 1.0 ppm Se diet at 13.8 months of age1.0 ppmfemales

   Effects of temporary selenium supplementation on the genesis of spontaneous mammary tumors in inbred female C3H/St mice

   Carcinogenesis·1 Feb 1980

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