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UNC0642

Intervention

1 paper3 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and 4 more
  • Animals1

Outcomes

3

Cell survival

upin mouse cells1

1 study

  1. UNC0642 increases cell survival in mouse cells.

    “In this setting, treatment with G9a inhibitor increases both cell survival and antioxidant enzymes.”

    Cellsin primary neuron cell cultures treated with hydrogen peroxide

    Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

    Neural regeneration research8 Jan 2024

PPARG

upin mice1

1 study

  1. UNC0642 increases PPARG in mice.

    “Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control group.”

    Animalsin SAMP8 mice

    Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

    Neural regeneration research8 Jan 2024

More on PPARG

miR-128

downin mice1

1 study

  1. UNC0642 decreases miR-128 in mice.

    “We found a downregulation of miR-128 after a G9a inhibition treatment”

    Animalsin SAMP8 mice

    Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

    Neural regeneration research8 Jan 2024

More on miR-128

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