Unacylated ghrelin
2 papers study it7 findings
Across all fields, 2 papers: none in people yet, 2 in animals
- 1 lab in 1 country
- 1 finding against
- Funders: National Institute on Aging and 2 more
- Animals2
Outcomes
6Muscle mass
downin mice1upin mice1
2 studies
Muscle mass
downin mice1upin mice1
Unacylated ghrelin protects against muscle mass in mice (partially protected against 20%-30% reduction).
“Gastrocnemius and quadriceps muscle weights were reduced by 20%-30% with age, which was partially protected against by UnAG.”
Animalsgastrocnemius and quadriceps10 months
Aging cell
Unacylated ghrelin improves muscle mass in mice (15-30%).
“unacylated ghrelin ameliorated loss of muscle mass by 15-30% in Sod1KO mice”
Animalsin Sod1KO mice
Antioxidants (Basel, Switzerland)
Body weight
no changein mice1
1 study
Body weight
no changein mice1
Unacylated ghrelin has no effect on body weight in mice.
“UnAG did not affect food consumption or body weight.”
Animals10 months
Aging cell
Synaptic transmission
upin mice1
1 study
Synaptic transmission
upin mice1
Unacylated ghrelin improves synaptic transmission in mice.
“Results of bulk mRNA-seq analysis and our contractile function data show that UnAG reversed neuromuscular junction impairment that occurs with age.”
Animals
Aging cell
Oxidative phosphorylation
downin mice1
1 study
Oxidative phosphorylation
downin mice1
Unacylated ghrelin protects against oxidative phosphorylation in mice.
“UnAG also protected from decreases in mitochondrial respiration and increases in hydrogen peroxide generation of skeletal muscle of old mice.”
Animalsskeletal muscle
Aging cell
Specific force
downin mice1
1 study
Specific force
downin mice1
Unacylated ghrelin protects against specific force in mice (prevented 30% loss).
“Specific force, force per cross-sectional area, measured in isolated extensor digitorum longus muscle was diminished by 30% in old mice; however, UnAG prevented the loss of specific force.”
Animalsextensor digitorum longus10 months
Aging cell
Contractile force
upin mice1+80%
1 study
Contractile force
upin mice1+80%
Unacylated ghrelin improves contractile force in mice (~80%).
“unacylated ghrelin prevented the force deficit by ~80%.”
Animalsin Sod1KO mice
Antioxidants (Basel, Switzerland)
Funding
3 grants since 2019National Institute on AgingUS$898.3k