Triheptanoin

Triheptanoin improves mitochondrial morphology in mice.

“decreased serum leptin and insulin, and improved mitochondrial morphology in skeletal muscle.”

AnimalsMecp2 knockoutskeletal muscle

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

PloS one·9 Oct 2014

Triheptanoin decreases adiposity in mice.

“Anaplerotic therapy in Mecp2 knockout mice also improved indicators of impaired substrate utilization, decreased adiposity, increased glucose tolerance and insulin sensitivity”

AnimalsMecp2 knockoutdietary therapy

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

PloS one·9 Oct 2014

Triheptanoin improves social interaction in mice.

“dietary therapy with triheptanoin significantly increased longevity and improved motor function and social interaction in male mice hemizygous for Mecp2 knockout.”

Animalshemizygous for Mecp2 knockoutdietary therapymales

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

PloS one·9 Oct 2014

Triheptanoin improves motor function in mice.

“dietary therapy with triheptanoin significantly increased longevity and improved motor function and social interaction in male mice hemizygous for Mecp2 knockout.”

Animalshemizygous for Mecp2 knockoutdietary therapymales

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

PloS one·9 Oct 2014

Triheptanoin extends lifespan in mice.

“dietary therapy with triheptanoin significantly increased longevity and improved motor function and social interaction in male mice hemizygous for Mecp2 knockout.”

Animalshemizygous for Mecp2 knockoutdietary therapymales

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

PloS one·9 Oct 2014