Trichostatin a
Across all fields, 9 papers: none in people yet, 2 in animals, 2 in cells, 2 reviews
- 4 independent labs in 4 countries
- 2 trials, none about aging
- Funders: Instytut Zootechniki – Państwowy Instytut Badawczy and others
- Animals1
- Model organisms1
- Cells1
- In silico3
Outcomes
9Immune-related gene expression
upin E. caballus cells1
1 study
Immune-related gene expression
upin E. caballus cells1
Trichostatin a increases immune-related gene expression in E. caballus cells.
“Selective upregulation of immune-related genes in TSA-stimulated chondrocytes”
Cellsfourth-passage cells expanded in 2D cultureprimary chondrocyteslow dose
Research in veterinary science
FOXO signaling-related gene expression
downin E. caballus cells1
1 study
FOXO signaling-related gene expression
downin E. caballus cells1
Trichostatin a decreases FOXO signaling-related gene expression in E. caballus cells.
“The unexpected transcriptional decline in FOXO signalling was characteristic of TSA-induced cartilage cells.”
Cellsfourth-passage cells expanded in 2D cultureprimary chondrocyteslow dose
Research in veterinary science
Proteasome pathway-related gene expression
upin E. caballus cells1
1 study
Proteasome pathway-related gene expression
upin E. caballus cells1
Trichostatin a increases proteasome pathway-related gene expression in E. caballus cells.
“Upregulation of genes involved in oxidative phosphorylation and the proteasome pathway is consistent with a potentially protective effect of TSA on mitochondrial homeostasis.”
Cellsfourth-passage cells expanded in 2D cultureprimary chondrocyteslow dose
Research in veterinary science
Oxidative phosphorylation-related gene expression
upin E. caballus cells1
1 study
Oxidative phosphorylation-related gene expression
upin E. caballus cells1
Trichostatin a increases oxidative phosphorylation-related gene expression in E. caballus cells.
“Upregulation of genes involved in oxidative phosphorylation and the proteasome pathway is consistent with a potentially protective effect of TSA on mitochondrial homeostasis.”
Cellsfourth-passage cells expanded in 2D cultureprimary chondrocyteslow dose
Research in veterinary science
Cell cycle-related gene expression
downin E. caballus cells1
1 study
Cell cycle-related gene expression
downin E. caballus cells1
Trichostatin a decreases cell cycle-related gene expression in E. caballus cells.
“We have identified downregulation of cell cycle and proliferation-related genes in TSA-stimulated chondrocytes.”
Cellsfourth-passage cells expanded in 2D cultureprimary chondrocyteslow dose
Research in veterinary science
Luteinizing hormone
upin rats1
1 study
Luteinizing hormone
upin rats1
Trichostatin a increases luteinizing hormone in rats.
“led to the restoration of Kiss1 neuronal activation and Kiss1 synthesis as well as circulating LH”
Animalsfemales
Bioscience trends
KISS1
upin rats1
1 study
KISS1
upin rats1
Trichostatin a increases KISS1 in rats.
“Restoration of physiological histone H3 acetylation by intracerebroventricular injection of trichostatin A (TSA) restored the expression of Kiss1”
Animalsanteroventral periventricular nucleusfemales
Bioscience trends
53BP1 recruitment to DSBs
no changein human cells1
1 study
53BP1 recruitment to DSBs
no changein human cells1
Trichostatin a has no effect on 53BP1 recruitment to DSBs in human cells.
“Induced hyperacetylation of late passage (LP) cells using trichostatin A increased H4K16Ac levels but did not ameliorate 53BP1 recruitment.”
Cellsin late passage cells
Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells
Biogerontology
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Trichostatin a extends lifespan in worms.
“An increase in lifespan and healthspan was observed for all drugs except geldanamycin when fed to wild-type worms”
Model organismsin wild-type worms
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans
Aging cell
Trials
0 about aging, of 2In trials
Phase 1Recruiting1 trial
Phase 1Recruiting1 trial
Phase 1Recruiting1 trial