53BP1 recruitment to DSBs

1. Trichostatin A has no effect on 53BP1 recruitment to DSBs in human cells.

   “Induced hyperacetylation of late passage (LP) cells using trichostatin A increased H4K16Ac levels but did not ameliorate 53BP1 recruitment.”

   Cellsin late passage cells

   Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells

   Biogerontology·Jul 18, 2022

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1. KAT8 is required for 53BP1 recruitment to DSBs in human cells.

   “Instead, deacetylation induced by MOF silencing reduced H4K16Ac levels and compromised 53BP1 recruitment in both EP and LP cells.”

   Cellsshown by silencing in EP and LP cells

   Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells

   Biogerontology·Jul 18, 2022

More on KAT8

1. H4K16ac is associated with 53BP1 recruitment to DSBs in human cells.

   “In vitro aged Human Dermal Fibroblasts (HDFs) display lower levels of H4K16A that correlate with reduced recruitment of 53BP1 to basal DSBs.”

   Cellsin in vitro aged cells

   Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells

   Biogerontology·Jul 18, 2022

More on H4K16ac