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TRAP1 inhibitor

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: British Heart Foundation and 2 more
  • Animals1

Outcomes

1

Atherosclerosis

downin mice1

1 study

  1. TRAP1 inhibitor decreases atherosclerosis in mice.

    “Additionally, pharmacological inhibition and proteolysis-targeting chimera (PROTAC)-mediated TRAP1 degradation effectively attenuated atherosclerosis in vivo.”

    Animalsin vivo

    TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation

    European heart journalAug 1, 2024

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