Tomatidine

1. Tomatidine decreases cellular senescence in mice.

   “reduced senescence markers (p16 Ink4a, p21 Cip1, and telomere-associated DNA damage foci) in liver, skin, and hippocampal neurons, along with decreased neuroinflammation and microglial activation”

   Animals

   Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

   EMBO molecular medicine·Apr 1, 2026

More on Cellular senescence

1. Tomatidine improves motor coordination in mice.

   “improved motor coordination and cognitive performance”

   Animals

   Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

   EMBO molecular medicine·Apr 1, 2026

1. Tomatidine improves cognitive function in mice.

   “improved motor coordination and cognitive performance”

   Animals

   Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

   EMBO molecular medicine·Apr 1, 2026

1. Tomatidine decreases frailty in mice.

   “In aged mice, tomatidine reduced frailty and improved motor coordination and cognitive performance.”

   Animals

   Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

   EMBO molecular medicine·Apr 1, 2026

1. Tomatidine decreases senescence-associated secretory phenotype (SASP) in human cells.

   “tomatidine selectively suppressed SASP expression without affecting p16Ink4a or p21Cip1 levels consistent with a senomorphic effect”

   Cellssenescent cells

   Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

   EMBO molecular medicine·Apr 1, 2026

More on Senescence-associated secretory phenotype (SASP)