Thiamphenicol

1. Thiamphenicol increases tight-junction proteins.

   “restored the expression of tight junction proteins (ZO-1, Occludin, Claudin-1)”

   AnimalsDSS-induced model

   Network pharmacology and experimental validation reveal Thiamphenicol ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of intestinal senescence and modulation of the NF-κB/AMPK signaling pathway

   Toxicology and applied pharmacology·30 Jul 2025

More on Tight-junction proteins

1. Thiamphenicol decreases pro-inflammatory cytokines.

   “downregulated pro-inflammatory cytokines (IL-1, IL-6, TNF-α) via NF-κB/AMPK modulation”

   AnimalsDSS-induced model

   Network pharmacology and experimental validation reveal Thiamphenicol ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of intestinal senescence and modulation of the NF-κB/AMPK signaling pathway

   Toxicology and applied pharmacology·30 Jul 2025

More on Pro-inflammatory cytokines

1. Thiamphenicol decreases senescent cells.

   “TP significantly reduced senescent cell accumulation”

   AnimalsDSS-induced model

   Network pharmacology and experimental validation reveal Thiamphenicol ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of intestinal senescence and modulation of the NF-κB/AMPK signaling pathway

   Toxicology and applied pharmacology·30 Jul 2025

More on Senescent cells

1. Thiamphenicol decreases colitis in mice.

   “attenuated DSS-induced colitis”

   Animalsin DSS-treated mice

   Network pharmacology and experimental validation reveal Thiamphenicol ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of intestinal senescence and modulation of the NF-κB/AMPK signaling pathway

   Toxicology and applied pharmacology·30 Jul 2025

More on Colitis

1. Thiamphenicol has no effect on antinuclear antibody in mice.

   “alter the pattern of ANA production”

   Animals50 mg/kg/dayfemales

   Thiamphenicol and lupus nephritis. II. The effects of giving the drug from weaning to NZBxOUW F1 hybrid female mice

   British journal of experimental pathology·1 Oct 1979

More on Antinuclear antibody

1. Thiamphenicol has no effect on anaemia in mice.

   “Thiamphenicol failed to influence greatly the progressive anaemia which develops in these mice or to alter the pattern of ANA production”

   Animals50 mg/kg/dayfemales

   Thiamphenicol and lupus nephritis. II. The effects of giving the drug from weaning to NZBxOUW F1 hybrid female mice

   British journal of experimental pathology·1 Oct 1979

More on Anaemia

1. Thiamphenicol extends lifespan in mice.

   “Thiamphenicol at the rate of 50 mg/kg/day given to female NZBxOUW F1 hybrid mice from weaning and continuing throughout life resulted in a considerable extension of lifespan”

   Animals50 mg/kg/dayfemales

   Thiamphenicol and lupus nephritis. II. The effects of giving the drug from weaning to NZBxOUW F1 hybrid female mice

   British journal of experimental pathology·1 Oct 1979