Thapsigargin
- 3 independent labs in 3 countries
- Funders: Consejo Nacional de Investigaciones Científicas y Técnicas and 2 more
- Animals1
Outcomes
3Trophoblast adhesion
downin human cells1
1 study
Trophoblast adhesion
downin human cells1
Thapsigargin impairs trophoblast adhesion in human cells.
“Functionally, these alterations impaired trophoblast adhesion and expansion in vitro.”
Cellsexacerbated ERS-induced prior to decidualization
How decidualization dysregulation reshapes the nanomechanics of endometrial stromal cells
Molecular human reproduction11 Apr 2026
Oxidative fiber abundance
upin cells1
1 study
Oxidative fiber abundance
upin cells1
Thapsigargin increases oxidative fiber abundance in cells.
“Treatment with a calcium channel inhibitor thapsigargin significantly increased the abundance of oxidative fibers.”
Cellsmuscle
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Cell death & disease28 Jun 2024
GDF-15
upin mouse cells1
1 study
GDF-15
upin mouse cells1
Thapsigargin increases GDF-15 in mouse cells.
“treatment of cultured mouse C2C12 myotubular cells with aging-related factors that mediate cellular stresses, such as oxidative stress (hydrogen peroxide) and endoplasmic reticulum stress (tunicamycin and thapsigargin), leads to an increase in GDF15 secretion.”
Cellsmyotubular cells
Biological & pharmaceutical bulletin1 Jan 2018
Latest
2 in 12 monthsBiology
miR-20487-5p/SERCA1/MAPK/ERK Pathway Regulates Newt Limb Regeneration
Experiments in animalsMAPK/ERK signalling
Molecular Human Reproduction
How decidualization dysregulation reshapes the nanomechanics of endometrial stromal cells
Case-control study in peopleMechanisms
Diabetologia
Regulating islet stress responses through CD47 activation
Study in peopleER unfolded protein response
eLife
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans
Experiments in model organismsMechanisms
bioRxiv
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans
Preprint: experiments in model organismsMechanisms
eLife
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans
Preprint: experiments in model organismsMechanisms
eLife
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans
Preprint: experiments in model organismsMechanisms
European Journal of Pharmacology
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries
Experiments in animalsMechanisms
Cell Death & Disease
Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Experiments in animalsMuscle