Terazosin
Intervention1 paper4 findings
- Animals1
Outcomes
4Palmitic acid
downin human cells1Very low certainty
1 study
Palmitic acid
downin human cells1Very low certainty
Terazosin decreases palmitic acid in human cells.
“TZ reduced palmitic acid accumulation by targeting MGLL, thereby mitigating endothelial senescence.”
Cellsin senescent endothelial cellsendothelial cell
Targeting MGLL: Terazosin Regulates Triglyceride Metabolism to Mitigate Endothelial Cell Senescence · GSA 2025 abstract · 31 Dec 2025
Cellular senescence
downin mice1Very low certainty
1 study
Cellular senescence
downin mice1Very low certainty
Terazosin decreases cellular senescence in mice.
“TZ treatment could significantly improve endothelial-dependent vasodilation, reduce vascular stiffness, and attenuate senescence markers in aged mice.”
Animalsin aged miceblood vessel
Targeting MGLL: Terazosin Regulates Triglyceride Metabolism to Mitigate Endothelial Cell Senescence · GSA 2025 abstract · 31 Dec 2025
Vascular stiffness
downin mice1Very low certainty
1 study
Vascular stiffness
downin mice1Very low certainty
Terazosin decreases vascular stiffness in mice.
“TZ treatment could significantly improve endothelial-dependent vasodilation, reduce vascular stiffness, and attenuate senescence markers in aged mice.”
Animalsin aged miceblood vessel
Targeting MGLL: Terazosin Regulates Triglyceride Metabolism to Mitigate Endothelial Cell Senescence · GSA 2025 abstract · 31 Dec 2025
Endothelial-dependent vasodilation
upin mice1Very low certainty
1 study
Endothelial-dependent vasodilation
upin mice1Very low certainty
Terazosin improves endothelial-dependent vasodilation in mice.
“TZ treatment could significantly improve endothelial-dependent vasodilation, reduce vascular stiffness, and attenuate senescence markers in aged mice.”
Animalsin aged miceblood vessel
Targeting MGLL: Terazosin Regulates Triglyceride Metabolism to Mitigate Endothelial Cell Senescence · GSA 2025 abstract · 31 Dec 2025