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Tauroursodeoxycholic acid

Intervention

3 papers3 findings

PubChem 9848818ChEBI 80774

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Model organisms1
  • Cells1

Outcomes

3

Reactive oxygen species

downin flies1

1 study

  1. Tauroursodeoxycholic acid decreases reactive oxygen species in flies.

    “In the fat body, mIHF+TUDCA reduced reactive oxygen species (ROS)”

    Model organismsin the fat bodyfat bodymales

    Maternal Tauroursodeoxycholic Acid Supplementation under Isocaloric High-Fat Diet Alleviates Oxidative Stress and Extends Lifespan through a whd-Dependent Mechanism in Drosophila Offspring

    The Journal of nutrition24 Mar 2026

More on Reactive oxygen species

Climbing performance

upin flies1

1 study

  1. Tauroursodeoxycholic acid improves Climbing performance in flies.

    “improved climbing performance at days 0 and 40 (P < 0.05).”

    Model organismsmaternal isocaloric high-fat dietmales

    Maternal Tauroursodeoxycholic Acid Supplementation under Isocaloric High-Fat Diet Alleviates Oxidative Stress and Extends Lifespan through a whd-Dependent Mechanism in Drosophila Offspring

    The Journal of nutrition24 Mar 2026

More on Climbing performance

Lifespan

upin flies1+19%

1 study

  1. Tauroursodeoxycholic acid extends lifespan in flies (+19.10%).

    “The mIHF+TUDCA diet significantly prolonged offspring lifespan compared with NC+TUDCA (+19.10%, P < 0.0001)”

    Model organismsmaternal isocaloric high-fat dietmales

    Maternal Tauroursodeoxycholic Acid Supplementation under Isocaloric High-Fat Diet Alleviates Oxidative Stress and Extends Lifespan through a whd-Dependent Mechanism in Drosophila Offspring

    The Journal of nutrition24 Mar 2026

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