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Targeting AP1 activity

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 6 more
  • Model organisms1

Outcomes

4

Oxidative damage

upin flies1

1 study

  1. Targeting AP1 activity increases oxidative damage in flies.

    “However, these benefits come at the cost of increased oxidative damage in the brain, and neuronal mitochondrial function remains poor.”

    Model organismsAP1 activity targeted in senescent gliabrain

    Senescent glia link mitochondrial dysfunction and lipid accumulation

    Nature5 Jun 2024

Lipid accumulation

downin flies1

1 study

  1. Targeting AP1 activity prevents lipid accumulation in flies.

    “Targeting AP1 activity in senescent glia mitigates senescence biomarkers, extends fly lifespan and health span, and prevents lipid accumulation.”

    Model organismssenescent glia

    Senescent glia link mitochondrial dysfunction and lipid accumulation

    Nature5 Jun 2024

Healthspan

upin flies1

1 study

  1. Targeting AP1 activity improves healthspan in flies.

    “Targeting AP1 activity in senescent glia mitigates senescence biomarkers, extends fly lifespan and health span, and prevents lipid accumulation.”

    Model organismssenescent glia

    Senescent glia link mitochondrial dysfunction and lipid accumulation

    Nature5 Jun 2024

Lifespan

upin flies1

1 study

  1. Targeting AP1 activity extends lifespan in flies.

    “Targeting AP1 activity in senescent glia mitigates senescence biomarkers, extends fly lifespan and health span, and prevents lipid accumulation.”

    Model organismssenescent glia

    Senescent glia link mitochondrial dysfunction and lipid accumulation

    Nature5 Jun 2024

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