SV40 large t antigen
SV40 large t antigen has been studied in 2 papers since 1992: none in people yet, 2 in cells. No study of it in people or animals has been published yet. The newest paper, Aug 18, 2022: “Tumor suppressors inhibit reprogramming of African spiny mouse ( Acomys) fibroblasts to induced pluripotent stem cells”.
2 papers study it2 findingsUpdated
None of its findings points the other way.
- 1 lab
- Funders: National Institute of Mental Health and 2 more
- Cells2
What did studies of SV40 large t antigen find?
2Studies of SV40 large t antigen measured 2 outcomes; the most studied are cellular senescence (1 study) and proliferative lifespan (1).
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
SV40 large t antigen prevents cellular senescence in human cells.
“These results clearly show that SV40 large T enables HTL to escape senescence.”
Cellsin human T lymphocytes
Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen
Experimental cell research
Proliferative lifespan
upin human cells1
1 study
Proliferative lifespan
upin human cells1
SV40 large t antigen extends proliferative lifespan in human cells (>170 doublings vs ~17 doublings).
“expression of T antigen extended the life span of T cell cultures.”
Cellsin pSV3neo-transfected human T lymphocytes
Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen
Experimental cell research