Somatostatin has been studied in 2 papers since 1996: none in people yet, 1 in cells, 1 review. No study of it in people or animals has been published yet. The newest story, Oct 4, 2026: “PTSD is linked to accelerated DNA methylation aging”.
Studies of Somatostatin measured 2 outcomes; the most studied are growth hormone-releasing hormone (1 study) and growth hormone release (1).
Growth hormone-releasing hormone
downin reviews1
Somatostatin inhibits growth hormone-releasing hormone.
“is negatively regulated by somatostatin (SST), GH and IGF1”
Review
Update on regulation of GHRH and its actions on GH secretion in health and disease
Reviews in endocrine & metabolic disorders
Growth hormone release
downin rat cells1
Somatostatin inhibits growth hormone release in rat cells.
“SS prevented GRF-stimulated GH release in most cases.”
Cellspituitarymales
Molecular and cellular endocrinology
National Institute on AgingUS$2.2m
In a preprint analyzing epigenome-wide data from thousands of U.S. veterans, posttraumatic stress disorder was significantly associated with accelerated DNA methylation…In a preprint analyzing epigenome-wide data from thousands of U.S. veterans, posttraumatic stress disorder was significantly associated with accelerated DNA methylation aging.