Calcitonin gene-related peptide
Calcitonin gene-related peptide has been studied in 4 papers since 1994: 1 observational study in people, 2 in animals, 1 review; 1 in the past year. The newest paper, Apr 14, 2026: “Multifunctional ions/drugs co-delivering nanocomposite hydrogel orchestrates neuro-osteogenic microenvironment for boosting osteoporotic osseointegration”.
- 1 lab in 1 country
- Funders: Japan Society for the Promotion of Science and 2 more
- Humans1
- Animals2
What did studies of Calcitonin gene-related peptide find?
4Studies of Calcitonin gene-related peptide measured 4 outcomes; the most studied are SOX9 (1 study), stem cell differentiation (1) and IL-2 (1).
SOX9
upin human cells1
1 study
SOX9
upin human cells1
Calcitonin gene-related peptide increases SOX9 in human cells.
“CGRP upregulated the gene expression of VEGF, SOX9, RUNX2, COL10a1, and MMP13 in the human ligament cells.”
Cellsligament
International journal of rheumatic diseases
Stem cell differentiation
upin human cells1
1 study
Stem cell differentiation
upin human cells1
Calcitonin gene-related peptide increases stem cell differentiation in human cells.
“CGRP also promoted chondrogenesis and osteogenesis from the human ligament cells.”
Cellsligament
International journal of rheumatic diseases
IL-2
downin mice1
1 study
IL-2
downin mice1
Calcitonin gene-related peptide inhibits IL-2 in mice.
“it inhibits IL-2 production in cloned splenic T cells.”
Reviewin cloned splenic T cellsspleen
The role of calcitonin gene-related peptide in the mouse thymus revisited
Annals of the New York Academy of Sciences
T cell proliferation
downin mice1
1 study
T cell proliferation
downin mice1
Calcitonin gene-related peptide inhibits T cell proliferation in mice.
“CGRP is a potent inhibitor of mitogen and antigen-stimulated proliferation of T cells”
Reviewmitogen and antigen stimulation
The role of calcitonin gene-related peptide in the mouse thymus revisited
Annals of the New York Academy of Sciences