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Sleep duration variability

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Humans1

Outcomes

2

Microbial richness

downin humans1

1 study

  1. Sleep duration variability decreases microbial richness in humans (β=-0.07 [-0.11, -0.03], p=0.002).

    “richness: β=-0.07 [-0.11, -0.03], p=0.002”

    Humansadjusted modeln = 276

    Variability in Objective Sleep Duration Associates with Gut Microbiota Composition and Metabolic Parameters—A Metagenomic Analysis in Healthy Subjects in a Community Study

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Microbial richness

Gut microbiota alpha diversity

downin humans1

1 study

  1. Sleep duration variability decreases gut microbiota alpha diversity in humans (adjusted β=-9.0 [-15.3, -2.6], p=0.006).

    “High sleep variability was negatively associated with gut microbiota alpha diversity (Shannon index: adjusted β=-9.0 [-15.3, -2.6], p=0.006”

    Humansadjusted modeln = 276

    Variability in Objective Sleep Duration Associates with Gut Microbiota Composition and Metabolic Parameters—A Metagenomic Analysis in Healthy Subjects in a Community Study

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Gut microbiota alpha diversity

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