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SIRT5 gene therapy

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Natural Science Foundation of Sichuan Province and 4 more
  • Animals1

Outcomes

2

Cellular homeostasis

upin mice1

1 study

  1. SIRT5 gene therapy improves cellular homeostasis in mice.

    “Increased SIRT5 expression by LV-SIRT5pcDNA in senescent AEC sustains mitochondrial integrity and reduces fibrotic effects of AEC senescence in established bleomycin (BLM)-aging mouse model.”

    Animalsin senescent alveolar epithelial cellslentiviral vector

    SIRT5-mediated desuccinylation prevents mitochondrial dysfunction in alveolar epithelial cells senescence and pulmonary fibrosis

    Cellular signalling29 Apr 2025

More on Cellular homeostasis

Pulmonary fibrosis

downin mice1

1 study

  1. SIRT5 gene therapy decreases pulmonary fibrosis in mice.

    “Increased SIRT5 expression by LV-SIRT5pcDNA in senescent AEC sustains mitochondrial integrity and reduces fibrotic effects of AEC senescence in established bleomycin (BLM)-aging mouse model.”

    Animalsin senescent alveolar epithelial cells in bleomycin-aging mouse modellentiviral vector

    SIRT5-mediated desuccinylation prevents mitochondrial dysfunction in alveolar epithelial cells senescence and pulmonary fibrosis

    Cellular signalling29 Apr 2025

More on Pulmonary fibrosis

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