Silk fibroin

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Beijing Nova Program and 6 more

Animals1

Outcomes

Cartilage-like tissue formation

upin reviews1

1 study

Silk fibroin induces cartilage-like tissue formation.
“Silk fibroin scaffolds consistently supported chondrogenesis and cartilage-like tissue formation.”
Reviewin preclinical cartilage repair models
Biomechanical Properties of Silk-Derived 3D Bioprinted Scaffolds for Cartilage Regeneration: A Comprehensive Review
Biomimetics (Basel, Switzerland)12 Aug 2026

Extracellular matrix remodelling

upin cells1

1 study

Silk fibroin improves extracellular matrix remodelling in cells.
“SF uniquely rejuvenates fibroblasts and restores ECM homeostasis through a non-inflammatory mechanism”
Cells
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
Bioactive materials6 Jan 2026

More on Extracellular matrix remodelling

Collagen degradation

downin cells1

1 study

Silk fibroin decreases collagen degradation in cells.
“thereby delaying collagen degradation in aged skin.”
Cellsaged skinskin
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
Bioactive materials6 Jan 2026

Oxidative stress and ROS signalling

downin cells1

1 study

Silk fibroin decreases oxidative stress and ROS signalling in cells.
“reducing reactive oxygen species (ROS) and matrix metalloproteinase (MMP) expression through modulation of the ROS-MAPK-AP-1-MMP signal pathway”
Cellsskin
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
Bioactive materials6 Jan 2026

More on Oxidative stress and ROS signalling

Cellular senescence

downin cells1

1 study

Silk fibroin inhibits cellular senescence in cells.
“reducing the accumulation of SASP factors and facilitating the transition of fibroblasts from a senescent to a functional state.”
Cells
Silk Fibroin Counteracts Fibroblast Senescence to Restore ECM Homeostasis in Aged Skin
Bioactive materials6 Jan 2026