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Silicon dioxide nanoparticles

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

3

Cellular senescence

upin mice1

1 study

  1. Silicon dioxide nanoparticles induce cellular senescence in mice.

    “Continuous oral ingestion of SiO2 NPs induced liver-specific accumulation, and caused abnormal deposition of liver lipids, senescence and fibrosis”

    Animalsliver12 w

    Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis

    Journal of nanobiotechnology10 Oct 2025

More on Cellular senescence

Liver fibrosis

upin mice1

1 study

  1. Silicon dioxide nanoparticles induce liver fibrosis in mice.

    “Continuous oral ingestion of SiO2 NPs induced liver-specific accumulation, and caused abnormal deposition of liver lipids, senescence and fibrosis”

    Animalsliver12 w

    Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis

    Journal of nanobiotechnology10 Oct 2025

More on Liver fibrosis

Silicon

upin mice1+165%

1 study

  1. Silicon dioxide nanoparticles increase silicon in mice (+165%).

    “ICP-OES revealed the silicon accumulation in the Liver, with 165% increase compared to the control”

    Animalssub-chronic oral ingestionliver12 w

    Orally ingested nanosilica causes liver-specific accumulation and induces liver senescence and fibrosis via the microbiota-gut-liver axis

    Journal of nanobiotechnology10 Oct 2025

More on Silicon

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