Shbg

1. Shbg increases PINK1 in E. caballus cells.

   “restore the protein levels of PINK, which is critically involved in mitochondria recycling machinery”

   Cellsin PPARγ knockdown equine ASCs

   Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells

   Journal of molecular medicine (Berlin, Germany)·Jun 14, 2024

More on PINK1

1. Shbg increases mitochondrial membrane potential in E. caballus cells.

   “SHBG treatment enabled to ameliorate the transmembrane potential”

   Cellsin PPARγ knockdown equine ASCs

   Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells

   Journal of molecular medicine (Berlin, Germany)·Jun 14, 2024

More on Mitochondrial membrane potential

1. Shbg has no effect on apoptosis in E. caballus cells.

   “loss in PPARγ triggers cell apoptosis which is not reversed by SHBG application”

   Cellsin PPARγ knockdown equine ASCs

   Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells

   Journal of molecular medicine (Berlin, Germany)·Jun 14, 2024

More on Apoptosis

1. Shbg decreases cellular senescence in E. caballus cells.

   “PPARγ knockdown cells exhibited premature senescence, which has been substantially alleviated by SHBG”

   Cellsin PPARγ knockdown equine ASCs

   Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells

   Journal of molecular medicine (Berlin, Germany)·Jun 14, 2024

More on Cellular senescence