Severe abdominal aortic calcification

1. alpha-Klotho lowers the risk of severe abdominal aortic calcification in humans (OR: 0.47, 95% CI: 0.19–0.74).

   “a 53% lower risk of Severe AAC in the highest α-Klotho quartile than in the lowest quartile (Quartile 4: OR: 0.47, 95% CI: 0.19–0.74, p = 0.01)”

   Humanshighest vs lowest quartile of serum alpha Klothon = 2,411

   Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification

   Scientific reports·9 Jan 2026

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