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Severe acute respiratory syndrome coronavirus 2 infection

Severe acute respiratory syndrome coronavirus 2 infection has been studied in 2 papers since 2022: 2 observational studies in people. The newest paper, Jan 1, 2025: “Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage”.

Exposure

2 papers study it4 findingsUpdated

“Although no overall differences in cellular senescence markers were observed between the COVID-19 positive and negative groups”
Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA DamageAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025doi:10.1111/aji.70034

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 7 more
  • Humans2

What did studies of Severe acute respiratory syndrome coronavirus 2 infection find?

4

Studies of Severe acute respiratory syndrome coronavirus 2 infection measured 4 outcomes; the most studied are DNA damage response (1 study), oxidative stress and ROS signaling (1) and senescence-associated secretory phenotype (SASP) (1).

DNA damage response

upin humans1

1 study

  1. Severe acute respiratory syndrome coronavirus 2 infection induces DNA damage response in humans.

    “Confocal microscopy of placentas from COVID-19 positive cases revealed localized areas of oxidative stress and DNA damage colocalized with SARS-CoV-2 spike protein.”

    Humanscolocalized with SARS-CoV-2 spike proteinplacenta

    Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage

    American journal of reproductive immunology (New York, N.Y. : 1989)

More on DNA damage response

Oxidative stress and ROS signaling

upin humans1

1 study

  1. Severe acute respiratory syndrome coronavirus 2 infection induces oxidative stress and ROS signaling in humans.

    “Confocal microscopy of placentas from COVID-19 positive cases revealed localized areas of oxidative stress and DNA damage colocalized with SARS-CoV-2 spike protein.”

    Humanscolocalized with SARS-CoV-2 spike proteinplacenta

    Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage

    American journal of reproductive immunology (New York, N.Y. : 1989)

More on Oxidative stress and ROS signaling

Senescence-associated secretory phenotype (SASP)

upin humans1

1 study

  1. Severe acute respiratory syndrome coronavirus 2 infection increases senescence-associated secretory phenotype (SASP) in humans.

    “we found increased secreted SASP markers.”

    HumansCOVID-19 positive pregnant womenplacenta

    Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage

    American journal of reproductive immunology (New York, N.Y. : 1989)

More on Senescence-associated secretory phenotype (SASP)

Cellular senescence

no changein humans1

1 study

  1. Severe acute respiratory syndrome coronavirus 2 infection has no effect on cellular senescence in humans.

    “Although no overall differences in cellular senescence markers were observed between the COVID-19 positive and negative groups”

    HumansCOVID-19 positive versus negative pregnant womenplacenta

    Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage

    American journal of reproductive immunology (New York, N.Y. : 1989)

More on Cellular senescence

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