Serum-free adipose-conditioned medium

Intervention

1 paper4 findings

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

4

IL-6 signalling

downin cells1

1 study
  1. Serum-free adipose-conditioned medium inhibits IL-6 signalling in cells.

    “associated with suppression of the IL-6/STAT3 signaling pathway”

    Cells

    A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression

    Stem cell research & therapy28 Nov 2025

More on IL-6 signalling

Aging-associated phenotypes

upin mice1

1 study
  1. Serum-free adipose-conditioned medium improves aging-associated phenotypes in mice.

    “SF-ACM improved aging-associated phenotypes in skin, adipose tissue, and skeletal muscle”

    AnimalsD-galactose-induced and naturally aged micemales

    A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression

    Stem cell research & therapy28 Nov 2025

Stem cell differentiation

upin human cells1

1 study
  1. Serum-free adipose-conditioned medium improves stem cell differentiation in human cells.

    “improved the proliferation, migration, and differentiation capacities of ADSCs”

    Cellssenescent ADSCs

    A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression

    Stem cell research & therapy28 Nov 2025

More on Stem cell differentiation

Cellular senescence

downin human cells1

1 study
  1. Serum-free adipose-conditioned medium decreases cellular senescence in human cells.

    “SF-ACM significantly reduced senescence-associated markers, including p16, p21, p53, and SA-β-gal”

    Cellsoxidative stress-induced and replicative senescence models

    A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression

    Stem cell research & therapy28 Nov 2025

More on Cellular senescence

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