Serum amyloid p component

Serum amyloid p component induces neuronal cell death in mouse cells.

“Furthermore, SAP can lead to neuronal cell death and a decline in synaptic density.”

Cellsin vitro

Induction of neurodegeneration in the hippocampus of senescence-accelerated mouse-prone 8 (SAMP8) mice by blood-brain barrier-crossing serum amyloid P component

Journal of neuroinflammation·21 Jan 2026

Serum amyloid p component increases blood-brain barrier permeability in mouse cells.

“SAP increased BBB permeability by altering the structure of occludin-positive tight junctions, as shown via in vitro analyses.”

Cellsin vitro

Induction of neurodegeneration in the hippocampus of senescence-accelerated mouse-prone 8 (SAMP8) mice by blood-brain barrier-crossing serum amyloid P component

Journal of neuroinflammation·21 Jan 2026