Senescent osteocyte-derived secretome
1 paper4 findings
- 1 lab in 1 country
- Cells1
Associations
4Neurodevelopmental and synaptic gene network expression
downin human cells1
1 study
Neurodevelopmental and synaptic gene network expression
downin human cells1
Senescent osteocyte-derived secretome is associated with neurodevelopmental and synaptic gene network expression in human cells.
“and suppression of neurodevelopmental and synaptic gene networks.”
CellsSingle iPSC line and single conditioned-medium batchconditioned mediumhuman cerebral organoidschronic exposure
Stem cells (Dayton, Ohio)12 Oct 2026
More on Neurodevelopmental and synaptic gene network expression
Extracellular matrix, inflammatory, and senescence pathway expression
upin human cells1
1 study
Extracellular matrix, inflammatory, and senescence pathway expression
upin human cells1
Senescent osteocyte-derived secretome is associated with extracellular matrix, inflammatory, and senescence pathway expression in human cells.
“This spatially heterogeneous biomechanical remodeling was accompanied by upregulation of extracellular matrix, inflammatory, and senescence pathways”
CellsSingle iPSC line and single conditioned-medium batchconditioned mediumhuman cerebral organoidschronic exposure
Stem cells (Dayton, Ohio)12 Oct 2026
More on Extracellular matrix, inflammatory, and senescence pathway expression
Spatially localized modulus
upin human cells1
1 study
Spatially localized modulus
upin human cells1
Senescent osteocyte-derived secretome is associated with spatially localized modulus in human cells.
“including lower apparent modulus in intact organoids and spatially localized regions of elevated modulus in cryosectioned specimens.”
CellsExploratory mechanical analyses using a single iPSC line and a single conditioned-medium batchconditioned mediumcryosectioned human cerebral organoidschronic exposure
Stem cells (Dayton, Ohio)12 Oct 2026
Apparent modulus
downin human cells1
1 study
Apparent modulus
downin human cells1
Senescent osteocyte-derived secretome is associated with apparent modulus in human cells.
“including lower apparent modulus in intact organoids and spatially localized regions of elevated modulus in cryosectioned specimens.”
CellsExploratory mechanical analyses using a single iPSC line and a single conditioned-medium batchconditioned mediumintact human cerebral organoidschronic exposure
Stem cells (Dayton, Ohio)12 Oct 2026