Neurodevelopmental and synaptic gene network expression

1. Senescent osteocyte-derived secretome is associated with neurodevelopmental and synaptic gene network expression in human cells.

   “and suppression of neurodevelopmental and synaptic gene networks.”

   CellsSingle iPSC line and single conditioned-medium batchconditioned mediumhuman cerebral organoidschronic exposure

   Paracrine Bone-Derived Senescent Secretome is Associated with Spatially Patterned ECM Remodeling and Altered Biomechanics in Human Brain Organoids

   Stem cells (Dayton, Ohio)·12 Oct 2026

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