Extracellular matrix, inflammatory, and senescence pathway expression

1. Senescent osteocyte-derived secretome is associated with extracellular matrix, inflammatory, and senescence pathway expression in human cells.

   “This spatially heterogeneous biomechanical remodeling was accompanied by upregulation of extracellular matrix, inflammatory, and senescence pathways”

   CellsSingle iPSC line and single conditioned-medium batchconditioned mediumhuman cerebral organoidschronic exposure

   Paracrine Bone-Derived Senescent Secretome is Associated with Spatially Patterned ECM Remodeling and Altered Biomechanics in Human Brain Organoids

   Stem cells (Dayton, Ohio)·12 Oct 2026

More on Senescent osteocyte-derived secretome